Ampicillin-sodium-D-minus-α-Aminobenzylpenicillin-sodium-salt-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAmpicillin sodiumCat. No.: HY-B0522ACAS No.: 69-52-3Synonyms: D-(-)-Aminobenzylpenicillin sodium salt分式: CHNNaOS分量: 371.39作靶點(diǎn): Bacterial作通路: Anti-infection儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性

2、數(shù)據(jù)體外實(shí)驗(yàn) H2O : 200 mg/mL (538.52 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.6926 mL 13.4629 mL 26.9259 mL5 mM 0.5385 mL 2.6926 mL 5.3852 mL10 mM 0.2693 mL 1.3463 mL 2.6926 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Ampicill

3、in sodium種譜-內(nèi)酰胺類抗素，可對抗多種蘭陽性和蘭陰性細(xì)菌(bacteria)。IC50 & Target Bacterial 1體外研究Ampicillin inhibits the growth of E. coli of swine origin in a dose-dependent manner. The effective inhibitory1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEconcentration of Ampicillin was 2.5 uG/mL 1.體內(nèi)研究 Ampicillin is very

4、effective in alleviating the symptoms of hemorrhagic enteritis in a 11-week old pig 1.Ampicillin produces maximum concentrations in bile twice as high as in serum. The peak concentration ofampicillin after an oral dose is as twice as high in portal blood as in peripheral blood 2. Ampicillin provides

5、neuroprotection against ischemia-reperfusion brain injury. Ampicillin reduces the activities of MMPs andincreases the expression level of GLT-1. Pretreatment with ampicillin significantly reduces medialhippocampal cell death following global forebrain ischemia 3.PROTOCOLAnimal Mice: Ampicillin is di

6、ssolved in normal saline. Male C57BL/6 mice were anesthetized with halothane andAdministration 3 subjected to bilateral common carotid artery occlusion for 40 min. Before transient forebrain ischemia,ampicillin (200 mg/kg, intraperitoneally i.p.) or penicillin G (6,000 U/kg or 20,000 U/kg, i.p.) was

7、administered daily for 5 days. In the control animals, saline was administered at the same volume and timeschedule 3.MCE has not independently confirmed the accuracy of these methods. They are for reference only.戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Biomed Res Int. 2018 Jul 2;2018:3579832.See more customer validations on HYP

8、ERLINK / www.MedChemEREFERENCES1. Chopra SL, et al. Effect of Ampicillin on E. Coli of Swine Origin. Can J Comp Med Vet Sci. 1963 Sep;27(9):223-7.2. Lund B, et al. Ampicillin in portal and peripheral blood and bile after oral administration of ampicillin andpivampicillin. Eur J ClinPharmacol. 1974;7(2):133-5.3. Lee KE, et al. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia. Korean J PhysiolPharmacol. 2016 Mar;20(2):185-92.McePdfHeightCaution: Product has not been fully validated for medical app