講稿綜述修改后

1、：麥冬作為一種滋陰藥，在傳統(tǒng)中藥中具有重要地位。麥冬的主要化學(xué)成分包括多糖、皂甙、高異：麥冬作為一種滋陰藥，在傳統(tǒng)中藥中具有重要地位。麥冬的主要化學(xué)成分包括多糖、皂甙、高異Research Progress of the Pharmacological Actions of Ophiopogon Japonicus ：japonicus, adrug whichcouldnourishYin,has ahesoftraditional medicine.The main constituents in Ophiopogon japonicus are polysaccharides，stero

2、id saponins, and isoflavonesThe Ophiopogon japonicus polysaccharide (OJP1) is the main medicinal component. With the constant in-depth study of Ophiopogon japonicus in recent years, its pharmacological activity has beenfound.Thispassage t OJP1 has various medical ch as immune regulation, anti-myocar

3、dial ischemia, anti-hypoxia and anti-allergyand so onthroughthe reviewysis of the onthepharmacologicalactionof OJP1，whichcouldoffersomeforthefurther 中藥麥冬是百合科（Liliaceae）多年生草本植物沿階草屬（Ophiopogon Ker Gawl） ，并能促進(jìn)使胰島細(xì)胞的恢復(fù)；提高機(jī)體免疫功能8具有抗心律失常的作用；、抗心肌缺血、抗過敏20等方面。本文次就麥冬效也主要集中在免疫活性李成蔭1等人通過選取NOD小鼠為干燥綜合征疾病模型，觀察麥冬多糖

4、對NOD小鼠頜下 韓鳳梅2等人對小鼠進(jìn)行60Co-射線全身照射和注射環(huán)磷酰胺韓鳳梅2等人對小鼠進(jìn)行60Co-射線全身照射和注射環(huán)磷酰胺，形成免疫損傷模型，對由60Co-射線和環(huán)磷酰胺造成的小鼠免損傷有一定的恢復(fù)作用，能顯著增強(qiáng)免疫茍興能3等人將小鼠置于放有鐵氧體磁體的小鼠籠中飼養(yǎng)，建立磁場模型組，通過磁場 , 增溶血素, , 鄭琴5等研究了麥冬多糖(MDG-1)對豚鼠離體心臟缺血再灌注損傷和皮下注射異丙腎 具有一定的保護(hù)作用。同時研究6發(fā)現(xiàn)另外一種麥冬多糖FOJ-5(相對分子質(zhì)量為5103- 具有一定的保護(hù)作用。同時研究6發(fā)現(xiàn)另外一種麥冬多糖FOJ-5(相對分子質(zhì)量為5103- 徐德生8等采用

5、異丙腎上腺素誘導(dǎo)大鼠心肌壞死的實(shí)驗(yàn)方法以ISO造成大鼠心肌壞對于麥冬多糖的抗心肌缺血的作用機(jī)制，研究8表明MDG-1可保護(hù)人 林曉9等人在對麥冬多糖進(jìn)行深入研究后發(fā)現(xiàn)對于麥冬多糖的抗心肌缺血作用研究已, OJP可以使缺血再灌的大鼠心臟收縮幅度和冠脈流量較快地恢復(fù), 抑制心率加快, .作用, 大 2 2 毛訊11以腹腔注射四氧嘧啶小鼠模型，用生理鹽水、二甲雙胍和兩種不同2 毛訊11以腹腔注射四氧嘧啶小鼠模型，用生理鹽水、二甲雙胍和兩種不同。顯抑制血糖升高，其降糖效果隨麥冬的產(chǎn)地不同而有差異。何陵湘12選用正常小鼠. 等13以空腹血糖值為指標(biāo)，觀察川麥冬蔗糖后血糖升高時間及降低血糖峰濃度 廖靖等1

6、4以小胰島素水平及C-反應(yīng)蛋白含量為觀察指標(biāo)，對鏈脲佐茵素造 活性，作用機(jī)制是通過減少胰島素抵抗來實(shí)現(xiàn)。Ding等16對麥冬多糖機(jī) 活性，作用機(jī)制是通過減少胰島素抵抗來實(shí)現(xiàn)。Ding等16對麥冬多糖機(jī)制進(jìn)行17Chen等18從麥冬根部中提取分離得到另一水溶性麥冬多糖OJP1，給予OJP1(150、制，研究19表明：1麥冬多糖能夠明顯的促進(jìn)脂肪細(xì)胞對血糖的轉(zhuǎn)運(yùn)和利用，從研究發(fā)現(xiàn)，麥冬多糖對呼吸系統(tǒng)有較明顯作用，具有抗過敏和平喘作用。湯軍等20過整體實(shí)驗(yàn), 觀察麥冬多糖200、50mg/kg) 皮膚過敏( PCA) 、等21通過對正常組大氧化物含量增加，紅細(xì)胞免疫功能下降等，導(dǎo)致衰老。皮下注射生理

7、鹽水, 并灌服溫開水; 等21通過對正常組大氧化物含量增加，紅細(xì)胞免疫功能下降等，導(dǎo)致衰老。皮下注射生理鹽水, 并灌服溫開水; 模型組大 灌服溫開水; , 許燕萍等22實(shí)驗(yàn)證明在大鼠頸總動脈結(jié)扎所致腦缺血實(shí)驗(yàn)中，結(jié)扎前給予麥冬多糖可缺血組織，防止細(xì)胞損害。提示麥冬多糖對腦缺血損傷有抗缺氧保護(hù)作用。莫正紀(jì)等23、，1Li CY,Wang Y,SunLX,Yan TT, TaoYF,WuS LProtectionof OphiopogonJaponicus onsubmandibularglandsinNoDmiceJ.JournalofImmunology, 2014(30):198-2HanF

8、M,Liu CX, ChenY.LowmountainOphiopogonJaponicuspolysaccharideontheimmuneiceJ. ChinaJournalOfTraditionalMedicine.2004.19(6):347-3Gou X N, Zhang X J l. Protective Effect of Ophiopogon polysaccharide On Immune Injuried Stable Magnetic ice. Journal of Sichuan of Traditional MedicineJ. 2009, 27(5):18-4Shi

9、 J X, Mao H Q, Hu Z Y. Ophiopogon Japonicas polysaccharide Stable Magnetic ice. Journal of Sichuan of Traditional MedicineJ. 2009, 27(5):18-4Shi J X, Mao H Q, Hu Z Y. Ophiopogon Japonicas polysaccharide of silkworm, life-span and oxidase on aging mice and the effect of serum hemolysinJ. China Journa

10、l Of Materia Medica. 5Zheng Q, Feng Y, Xu D S. Protective Effect of Ophiopogonis Polysaecharide MDG-1 on MyocardialIschemicRatsJ.JournalegrativeMedicine.2007,27(12):1116-Zheng Q, Feng Xu D S, et a1. Influence of sulfation on anti-myocardial ischemic activity of Ophiopogon japonicus polysaccharideJJA

11、sian Nat Prod Res, 2009, 11(4):306-321.Xu D S, Feng Y, Zhou Y H. Active components of Polysaccharide of Ophiopogon Japonicus on myocardialischemiaJ.Proprietarymedicine.2004,26(10):832-8WangS, ZhangZ, LinX,et a1Apolysaccharide, MDG-1,S1P1andbFGFandsurvival and he ischemic heartJ. Glycobiology, 2010,

12、20(4):473-9Ling X , Lu Z L, Xu D S , Feng Y. Comparison of distribution of Ophiopogon Japonicas polysaccharide hearts of normal rats and myocardial ischemic ratsJ. China Journal Of Materia Medica. Tang J, Hypoglycemic Activity and Protection Effect of Ophiopogon Japonicus Polysaccharide in Diabetic

13、and Impaired Glucose Regulation Rats, Master degree theses of master of WenZhou Medical College. Mao X . Study on the effect of diabetic mice with polysaccharide in ophiopogonjaponicus. Clinical of Medicine2013Vo1(5) No.17:4-12He L X.The Pharmacodynamic observation of ophiopogonpolysaccharides effec

14、t on Reducing Blood LevelsJ, Chinapracticalmedcine,2007,2(16): 48-13Zhang K Q, Gou Z R, et. Research on Reducing Blood Sugar Levels of Sichuan polysaccharideJ,SichuanTraditionalMedicine, 2012, 30(2): 58-14Liao J, Cai D H. Effects of Ophiopogon polysaccharide on miceJ.Qilu PharmaceuticalA irs,2011,30

15、(8):435-of ges ional diabetes 15Xu J, Xu D S, et a1Hypoglycemic effects of MDG-1, a polysaccharide derived from heob/obmouseoftype2diabetesJ BiolMacromol,2011,49:657-Ding L, Li Lau C B, a1. Mechanistic studies on the antiabetic activity of a polysaccharide-rich extract of Radix Ophiopogon J. Phytoth

16、erRes, 2012, 26(1): 101-105.Wang L Y , Wang S, Wang Y , et . Effect of MDG-1 on oral glucose tolerance andestinalmicroecological betic mice. World ChiJournal of Digestology. 2011,19(19):20582062.Chen X M, Jin J, Tang J, etal. Extraction, purification, characterization and hypoglycemie activity of ap

17、olysaccharide isolated from the root of OphiopogonjaponicusJCarbohydrate Polyme, 2011,83(2):749-Chen L. Experimental research on the active mechanism of the sensibility of OPSR to adipocyte insulin, mastersdegreethesisofHebeiiversity,20Tang J , Qian H, Huang Q. A study on the antianaphylactin and an

18、tiasthmatic antivity of fromophiopgpnistuberJ.Chinajournalofmodernapp dpharmacy.1999,16(2):16-21Zhang Y S, Liu X Z, Li H. Ophiopogon Japonicus anti-aging effect of research on aging rats ShenzhenJournalegratedTraditionalandWesternMedicine,1999,19(6):26-P , Chen Q . Ophiopogon Japonicus Polysaccharides Protection Against CerebrumIschameia. Journal Of Zheng Jiang Medical College, 1999, 19(6):26-27.Mo Z