Ketotifen-d3-HC-20-511-d-sub-3-sub-生命科學試劑-MCEVIP

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEKetotifen-d3Cat.No.:HY-B0157S1CASNo.:126939-17-1Synonyms:HC20-511-d3分?式:C??H??D?NOS分?量:312.44作?靶點:Isotope-LabeledCompounds;InfluenzaVirus;SARS-CoV;HistamineReceptor;EndogenousMetabolite作?通路:Others;Anti-infection;GPCR/GProtein;Immunology/Inflammation;NeuronalSignaling;MetabolicEnzyme/Protease儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Ketotifen-d3(HC20-511-d3)氘代標記的Ketotifen.Ketotifen(HC20-511)?種具有?服活性的第?代?競爭性組胺1(H1)受體阻滯劑和肥?細胞穩(wěn)定劑。Ketotifen可在體外阻斷6-磷酸葡萄糖酸脫氫酶(6-PGD)。Ketotifen還對SARS-CoV-2和流感病毒(Influenzavirus)具有抗病毒活性。Ketotifen可?于??免疫性腦脊髓炎(EAE)和預防哮喘發(fā)作的研究。體外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-216.[2].KlookerTK,etal.Themastcellstabiliserketotifendecreasesvisceralhypersensitivityandimprovesintestinalsymptomsinpatientswithirritablebowelsyndrome.Gut.2010Sep;59(9):1213-21.[3].ZhangH,etal.Advancesinthediscoveryofexosomeinhibitorsincancer.JEnzymeInhibMedChem.2020;35(1):1322-1330.[4].KianiP,etal.InVitroAssessmentoftheAntiviralActivityofKetotifen,IndomethacinandNaproxen,AloneandinCombination,againstSARS-CoV-2.Viruses.2021Mar26;13(4):558.[5].EnkirchT,etal.IdentificationandinvivoEfficacyAssessmentofApprovedOrallyBioavailableHumanHostProtein-TargetingDrugs1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEWithBroadAnti-influenzaAActivity.FrontImmunol.2019Jun5;10:1097.[6].PinkeKH,etal.CalmingDownMastCellswithKetotifen:APotentialStrategyforMultipleSclerosisTherapy?Neurotherapeutics.2020Jan;17(1):218-234.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly