免疫學部分習題0.docx

A 1 MALT內(nèi)的B細胞分化為漿細胞后主要分泌何種抗體 A IgA B IgGG C IgE D IgD E IgMD 2 機體抵抗病原微生物感染的功能稱為 A 免疫監(jiān)視 B 免疫自穩(wěn) C 免疫耐受 D 免疫防御 E 免疫識別C 3 T細胞識別的抗原必須具備 A T細胞表位和B細胞表位 B TCR和BCR C T細胞表位和限制位 D 連續(xù)性決定簇和功能性決定簇 E 構(gòu)象決定簇和順序決定簇C 4 除了免疫原性以外，抗原的特性還有 A 毒性 B 變態(tài)反應原性 C 異嗜性 D 耐受性 E 抗原性A 5 人類B淋巴細胞分化成熟的場所是： A 骨髓 B 腔上囊 C 脾臟 D 胸腺 E 淋巴結(jié)C 6 機體免疫系統(tǒng)殺滅突變的腫瘤細胞的功能稱為 A 免疫防御 B 免疫應答 C 免疫監(jiān)視 D 免疫穩(wěn)定 E 免疫識別B 7 IL-2主要有哪種細胞產(chǎn)生？ A Tc細胞 B TH細胞 C M D B細胞 E Ts細胞A 8 機體免疫系統(tǒng)識別和清除突變的細胞的功能稱為 A 免疫監(jiān)視 B 免疫自穩(wěn) C 免疫耐受 D 免疫防御 E 免疫識別E 9 IL-1主要由哪種細胞產(chǎn)生 A TH B TC C TDTH D TS E 巨噬細胞E 10 關于IgG的錯誤敘述是 A 可分為四個亞類 B 可通過胎盤 C 抗原結(jié)合價為二價 D CH2有補體C1q結(jié)合點 E 經(jīng)木瓜蛋白酶水解后可獲得一個F（ab）2片段D 11 發(fā)現(xiàn)ABO血型抗原的學者是 A Jerne B Burnet C Medawar D Landsteiner E BehringC 12 無胸腺小鼠體內(nèi)缺乏 A 成熟樹突狀細胞 B 成熟B細胞 C 成熟T細胞 D 成熟單核細胞 E 成熟粒細胞D 13 存在于不同種屬之間的共同抗原稱為 A 異種抗原 B 交叉抗原 C 超抗原 D 異嗜性抗原 E 類屬抗原C 14 MHC分子參與細胞分化過程正確的是 A 造血干細胞分化為淋巴干細胞 B 淋巴干細胞分化為前T細胞 C 前T細胞分化為成熟T細胞 D 成熟T細胞分化為記憶T細胞 E 淋巴干細胞分化為B細胞E 15 編碼補體成分的基因位于: A TAP座位 B HLA-DR座位 C HLA-E座位 D HLA-A座位 E Bf座位D 16 補體經(jīng)典激活途徑的依次順序是 A C123456789 B C12456789 C C145236789 D C142356789 E C124356789E 17 補體固有成分中含量最低的是 A C3 B C8 C C1q D C5 E D因子C 18 刺激紅細胞產(chǎn)生的細胞因子為 A GM-CSF B G-CSF C EPO D M-CSF E TPOE 19 補體系統(tǒng)中D因子的功能是 A 使C3b滅活 B 作為C5轉(zhuǎn)化酶的基質(zhì) C 過敏毒素 D 趨化因子 E 將C3bB裂解為活化的C3bBb和BaD 20 B細胞記憶是B細胞再次遇到相同抗原時產(chǎn)生的 A 低效價、低親和力抗體的現(xiàn)象 B 低效價、高親和力抗體的現(xiàn)象 C 高效價、低親和力抗體的現(xiàn)象 D 高效價、高親和力抗體的現(xiàn)象 E 非特異性抗體的現(xiàn)象D 21 黏膜相關淋巴組織中的B細胞主要分泌 A IgG類抗體 B IgM類抗體 C IgE類抗體 D IgA類抗體 E IgD類抗體D 22 T細胞CD4分子識別MHC類分子的位點是 A 1區(qū) B 2區(qū) C 1區(qū) D 2區(qū) E 鏈D 23 TD抗原激活B細胞需要 A Tc細胞的輔助 B NK細胞的輔助 C 中性粒細胞的輔助 D Th細胞的輔助 E 肥大細胞的輔助A 24 HLA類基因編碼的產(chǎn)物是 A MHC類分子的鏈 B MHC類分子的鏈 C MHC類分子的鏈 D MHC類分子的鏈 E C2、C4、TNFC 25 關于IgG的特性，下列哪項是正確的 A C區(qū)有4個功能區(qū) B 是胚胎晚期合成的主要抗體 C 是唯一通過胎盤的抗體 D 是天然的血型抗體 E 是分子量最大的抗體B 26 B細胞具有識別特異性抗原的功能，因其表面有 A E受體 B mIg C sIgA D C3受體 E FC受體C 27 表達于B細胞表面的CD40是 A BCR復合體 B CD19/CD21/CD81/CD225 C 協(xié)同刺激分子 D C3d受體 E BCR識別特異性抗原E 28 發(fā)現(xiàn)免疫球蛋白基因重排規(guī)律的學者是 A Cantor B Claman C Warner D ChaseE: E TonegawaC 29 根據(jù)移植物來源,哪種腎存活率最高: A 異種腎 B 同種腎 C 同卵雙生同胞供體腎 D 親屬供體腎 E 父母的腎B 30 補體的溶菌作用屬于 A 特異性免疫應答 B 非特異性免疫應答 C 固有免疫應答 D 免疫穩(wěn)定功能 E 適應性免疫應答A 31 參與補體旁路激活途徑 A B因子 B C4 C 阻止經(jīng)典途徑C3轉(zhuǎn)化酶形成 D 損傷細胞 E 阻止膜攻擊復合物的形成C 32 IL-4 A 裂解靶細胞 B 促進T細胞克隆擴增的主要細胞因子是 C 誘導初始T細胞分化為TH2 D 表達于活化T細胞表面，與活化誘導的細胞死亡有關 E 與活化M有關D 33 關于型干擾素的生物學活性的敘述應除下列哪項? A 激活單核巨噬細胞 B 抑制病毒的復制 C 抑制細胞增生 D 促進IL-4的產(chǎn)生 E 促進CTL成熟E 34 抗原特異性淋巴細胞是指 A 只是T淋巴細胞 B 只是B淋巴細胞 C NK細胞 D T淋巴細胞和NK細胞 E T淋巴細胞和B淋巴細胞D 35 受抗原刺激后，淋巴結(jié)的皮質(zhì)區(qū)見有 A 初級濾泡 B 淋巴索 C 淋巴竇 D 生發(fā)中心 E 冠狀帶B 36 NK細胞的生物學作用包括 A 特異性殺傷作用 B ADCC作用 C 免疫復合物清除作用 D 吞噬靶細胞 E 誘導急性變態(tài)反應的發(fā)生B 37 產(chǎn)生IL-2的細胞是 A 巨噬細胞 B T細胞 C B細胞 D 肥大細胞 E NK細胞B 38 各種Ig單體分子共有的特性是 A 與靶細胞結(jié)合后能介導ADCC作用 B 具有兩個完全相同的抗原結(jié)合部位 C 輕鏈與重鏈以非共價鍵結(jié)合 D 與抗原結(jié)合后能激活補體 E 與顆粒性抗原結(jié)合后能介導調(diào)理吞噬作用C 39 MHC是指 A 不同染色體上編碼組織相容性抗原的基因群 B 同一染色體上編碼次要組織相容性抗原的基因群 C 同一染色體上由一組高度多態(tài)性編碼主要組織相容性抗原的基因群 D 不同染色體上的緊密連鎖的基因群 E 任一染色體上的一組基因群A 40 MHC分子與抗原肽結(jié)合的部位在 A 多態(tài)性區(qū) B 非多態(tài)性區(qū) C 跨膜區(qū) D 胞漿區(qū) E 胞膜外區(qū)B 41 型超敏反應是由哪類抗體介導的 A IgG B IgE C IgA D IgD E IgMC 42 接種人痘預防天花的發(fā)明者是 A 英國人 B 法國人 C 中國人 D 荷蘭人 E 日本人B 43 被活化后可產(chǎn)生介導炎癥反應片段的補體成分是 A C1和C2 B C3和C5 C C6和B因子 D C7和C8 E C4和C9E 44 體液免疫，初次免疫應答的潛伏期大約為 A 25天 B 36天 C 02天 D 45天 E 710天B 45 B細胞活化輔助受體包括 A BCR復合體 B CD19/CD21/CD81/CD225 C 協(xié)同刺激分子 D C3d受體 E BCR識別特異性抗原B 46 關于IL-4的生物學功能的敘述，下列哪項應除外？ A 誘導B細胞，發(fā)生免疫球蛋白重鏈的類別轉(zhuǎn)換 B 刺激B細胞及巨噬細胞表達MHC類分子 C Th2細胞的自分泌生長因子 D 促進胸腺細胞和T細胞增生 E 肥大細胞的生長因子D 47 免疫細胞產(chǎn)生、發(fā)育、分化成熟的場所是 A 淋巴結(jié)和胸腺 B 淋巴結(jié)和骨髓 C 骨髓和脾臟 D 骨髓和胸腺 E 淋巴結(jié)和脾臟D 48 APC上的B7的配體是 A CD2 B CD4 C CD8 D CD28 E CD16E 49 T細胞主要位于外周淋巴組織中的: A 淋巴小結(jié) B 脾小結(jié) C 脾臟紅髓 D 胸腺皮質(zhì) E 脾臟中央小動脈周圍淋巴鞘D 50 傳導B細胞第一活化信號的分子是 A mIg B 抗原分子 C BCR D Ig/Ig E MHC分子 A 51 人體再次體液免疫應答發(fā)生的場所是: A 外周免疫器官 B 淋巴結(jié) C 骨髓 D 胸腺 E 法氏囊C 52 型超敏反應中具有重要調(diào)節(jié)作用的細胞是 A 中性粒細胞 B 嗜堿性粒細胞 C 嗜酸性粒細胞 D 肥大細胞 E 血小板A 53 非胸腺依賴性抗原的命名是由于 A 它能直接刺激B細胞產(chǎn)生抗體，無需T細胞參與 B 抗原來源于非胸腺組織 C 它誘生的抗體在骨髓中產(chǎn)生 D 它誘生的抗體屬于IgA E 它常具有多種復雜的抗原決定簇A 54 NK細胞的受體包括 A KAR和KIR B TCR和CR C KAR和BCR D KIR和CR E CDR和KIRA 55 對人體沒有免疫原性的物質(zhì)是： A 自身移植的皮膚 B 異體移植的皮膚 C 自身釋放的晶體蛋白 D 動物的免疫血清 E 異種血型的紅細胞E 56 輔助HIV感染T細胞的細胞因子是 A IFN B IL-8 C IL-2 D CD4 E CCR5C 57 型超敏反應的啟動因素是 A 細胞因子 B 免疫球蛋白 C 免疫復合物 D 單核吞噬細胞 E 淋巴毒素D 58 B細胞區(qū)別于其他APC的特點是 A 吞噬攝取抗原 B 胞飲攝取抗原 C 通過甘露糖受體攝取甘露糖化抗原 D 通過BCR直接攝取抗原 E 通過FC受體攝取抗原抗體復合物D 59 參與攻膜復合物的形成 A B因子 B C4 C C2 D C6 E D因子A 60 免疫缺陷的病人易發(fā)生 A 腫瘤 B 過敏性休克 C 接觸性皮炎 D 自身免疫性溶血性貧血 E 強直勝脊柱炎C 61 關于Ig正確的敘述是 A 同種紅細胞凝集素為IgG B 分泌型IgA一般為五聚體 C IgM類抗體合成障礙的患者易發(fā)生菌血癥 D IgM類抗體能通過胎盤 E IgD的Fc段容易同肥大細胞結(jié)合C 62 IFN-主要由下列哪種細胞產(chǎn)生? A LAK細胞 B 巨噬細胞 C NK細胞 D 成纖維細胞 E B淋巴細胞A 63 病毒持續(xù)感染 A 生理性免疫防御功能低下 B 生理性免疫穩(wěn)定 C 免疫監(jiān)視功能失調(diào) D 免疫穩(wěn)定功能失調(diào) E 免疫防御作用過高B 64 ABO血型抗原屬于 A 自身抗原 B 同種異型抗原 C 超抗原 D 獨特型抗原 E 異嗜性抗原E 65 關于抗體，下列哪項描述是不準確的 A 抗體是指具有免疫功能的球蛋白 B 抗體主要存在于血液、體液、粘膜表面及其分泌液中 C 抗體是能和相應抗原特異性結(jié)合的球蛋白 D 抗體都是免疫球蛋白 E 抗體都是體內(nèi)產(chǎn)生的E 66 免疫對機體 A 是有益的反應 B 是有害遠大于有益的反應 C 是有害的反應 D 無益也無害的反應 E 正常條件下對機體有益，但在一定條件下對機體有害B 67 HLA類基因區(qū)可編碼的因子是 A IFN B TNF C TGF- D IL-2 E EPOE 68 MHC類分子 A 只存在于紅細胞上 B 只存在于白細胞上 C 只存在于淋巴細胞上 D 只存在于巨噬細胞上 E 存在于一切有核細胞上C 69 創(chuàng)建雜交瘤技術制備單克隆抗體的學者是 A Koch和Pasteur B Miller和Good C Milstein和Kohler D Tiselius和Kabat E Porter和EdelmanD 70 關于ADCC的敘述，下列哪項是正確的 A IgM可介導ADCC B M不具有ADCC C CTL可通過ADCC殺傷靶細胞 D ADCC的殺傷作用是非特異性的 E ADCC需要補體參與B 71 對中性粒細胞有趨化作用的是 A IFN B IL-8 C IL-2 D L-12 E CCR5C 72 合成分泌片的細胞是 A B細胞 B 漿細胞 C 上皮細胞 D T細胞 E 巨噬細胞A 73 NK細胞主要存在于 A 血液和淋巴樣組織，特別是脾臟 B 血液和淋巴樣組織，特別是肝臟 C 血液和淋巴樣組織，特別是腎臟 D 血液和淋巴樣組織，特別是肌肉 E 血液和淋巴樣組織，特別是皮下A 74 具有中和作用的血清抗體主要是 A IgG B IgA C IgD D IgE E IgMB 75 促使輔助性T細胞分化為Th1細胞的細胞因子有 A IL-1 B IL-2 C IL-4 D IL-10 E CCR5C 76 關于HLA類分子的正確敘述是 A 2條多肽鏈均為MHC編碼 B 人類的MHC類分子包括HLA-DR、HLA-DQ、HLA-DP C 主要存在于抗原提呈細胞的表面，調(diào)控體內(nèi)體液免疫和細胞免疫應答 D 較少分布于各種有核細胞表面 E HLA類分子由第六染色體短臂上HLA復合體編碼C 77 B細胞在抗原刺激及Th細胞的輔助下，增殖活化為 A 殺傷性細胞 B 吞噬細胞 C 漿細胞 D 輔助性細胞 E 細胞毒性細胞A 78 激活補體能力最強 A IgM B IgG C IgE D IgA E IgDA 79 既參與固有性免疫應答又參與適應性免疫應答的成分有 A 巨噬細胞 B B細胞 C T細胞 D 中性粒細胞 E 漿細胞D 80 關于免疫球蛋白正確的敘述是 A IgG的H鏈是鏈 B 抗原結(jié)合于Ig的恒定區(qū) C IgA能通過胎盤 D IgE引起型超敏反應 E IgM的半衰期為23天 1，A decade ago, Nancy did what so many Americans dream about. She quit an executive position and opened/ set up a household device store in her neighborhood. People like Nancy made the decision primarily for the improvement in the quality of their lives. But, to run a small business on a small scale is by no means an easy job. Without her steady income, Nancy had to cut back on her daily expense. Sometimes she did not even have the money to pay the premium for the various kinds of insurance she needed. Fortunately, through her own hard work, she has now got through the most difficult time. She is determined to continue pursuing her vision of a better life. ,2， Shortly after he achieved freedom Henson became intent on assisting fugitive slaves. He secretly returned to the United States from Canada several times to help others to travel the Underground Railroad to freedom. Once some slave catchers closed in on the escaping slaves and Henson when they were on the run. He disguised them and successfully avoided capture. Later he built a small settlement in Dresden in Canada for escaped slaves, setting up a chapel and a school. He held to the conviction that slavery would be abolished, and the day was bound to come when racial discrimination no longer existed. 3，It is almost impossible to keep a determined burglar out. All you can do is discourage him for a few minutes. Thus exposing him to police patrols. Common sense tells us that lighting is a barrier to criminal activity. A light should be fixed in the doorway and switched on at night. Make sure/Assure yourself that you dont leave the door on the latch if you happen to be the last to come in. If you decide to buy a sophisticated electronic alarm system, be sure to ask for its signs and put them up on both windows and doors. In addition you may have it hooked up to a police station 4，What was remarkable about 2005 was perhaps that the UN declared it The World Year of Physics. It was the 100th anniversary of Einsteins theory of relativity and the 50th anniversary of his death. In 1905 Einstein published five highly important essays in the history of science, thus revolutionizing physics. His great achievements can be credited to his impressive powers of imagination, constant questioning, and not giving a fig for authority. It is beyond doubt that Einstein was the greatest scientist in the 20th century. 5，Amid the atmosphere of Thanksgiving, rather than joining his friends in celebration of the holiday, George was immersed in the diary left to him by his father, who died at sea after he completed two successive trips around the world. The diary brought back every moment George had spent with his father and many of the specific things his father did on his behalf. Georges father used to impress on him the need to undergo all kinds of hardship in quest of excellence. He also taught him that nothing in the world could be taken for granted. Even today, George still remembers how his father would quote Aesops famous saying Gratitude is the sign of noble souls and tell him to accord the greatest importance to it. 6，Here and there we see young artists who stand out from other people. They may be in worn-out jeans all the year round, or walk barefoot / in bare feet even in winter, or drink to excess, or cling to the fancy of creating a masterpiece without actually doing any creative work. In fact，many of them act like this just to look the past ，or to be in tune with other artists ，they have forgotten that only thorough persistent effort can one achieve success。 7，Tom was born a cripple, with one of his lower limbs useless. Early in his childhood, he learned that unless he so exerted himself as to rise above his limitations, he could not earn a living, and unless he succeeded in making a living on his own, he could not win/gain the respect of others. That was the price he had to pay for his dignity as a human being. Tom applied for numerous jobs, only to be turned down, before he finally got one as a delivery boy for a Pizza Hut. He then worked as a sales representative for a sportwear company in a territory no one else would want. Today he owns a fairly profitable retail shop in his hometown, and hires several people to work for him ,8，The majority of scientists are adamantly opposed to reproductive cloning and support therapeutic cloning for treating diseases. The reason is that therapeutic cloning does not involve any type of risk to human life and actually provides tremendous potential for the r