NCCN食管癌化療指南

1、術前化療：1 紫杉醇和卡鉗 紫杉醇 paclitaxel 卡鉗 carboplatinAUG濃度時間曲線下面積Paclitaxel 50 mg/m2 IV on Day 1Carboplatin AUC 2IV on Day 1Weekly for 5 weeks2,32 順鉗和氟喀喘Cisplatin 順鉗Fluropyrimidinc氟卩密卩定Capccitabinc卡培他濱5-FU: 5氟尿喀唳PO: 口服BID:日2次Infusion:輸液Cisolatin and fluoroDyrimidineCisplatin 75-100 mg/m2 IV on Days 1 and 29 5

2、FU 750-1000 mg/m2 IV continuous infusion over 24 hours daily on Days 1-4 and 29-32 35-Day cycle4Cisplatin 30 mg/m2 IV on Day 1 Capecitabine 800 mg/m2 PO BID on Days 1-5 Weekly for 5 weeksCisplatin 15 mg/m2 IV daily on Days 1-5 5FU 800 mg/m2 IV continuous infusion over 24 hours daily on Days 1-5Cycle

3、d every 21 days for 2 cycles63 奧沙利鉗+氟卩密唳Oxaliplatin and fluoropyrimidinwOxaliplatin 45 mg/m2 IV on Day 1 weekly for 5 weeks 5-FU 225 mg/m2 IV continuous infusion over 24 hours daily on Days 1-337Oxaliplatin 85 mg/m2 IV on Days 1, 15, and 29 for 3 doses 5-FU 180 mg/m2 IV daily on Days 1-338Oxaliplati

4、n 85 mg/m2 IV on Days 1,15, and 29 for 3 doses Capecitabine 625 mg/m2 PO BIDon Days 1-5 for 5 weeks94紫杉烷+氟眩唏Taxane and fluoropYrimiUinePaclitaxel 45-50 mg/m2IV on Day 1 Capecitabine 625-825 mg/m2PO BID on Days 1-5 Weekly for 5 weeks13-14Docetaxel 20 mg/m2 IV on Day 15-FU 200-300 mg/m2 IV daily on Da

5、ys 1-5 Weekly for 5 weeks 151&Docetaxel 20 mg/m2 IV on Day 1Capecitabine 625-825 mg/m2P0 BID on Days 1-5 Weekly for 5 weeks5奧沙利鉗+紫杉菇+卡培他濱Oxaliplatin, docetaxM and Gapecitabinw Oxaliplatin 40 mg/m2 IV on Days 1, 8,15,22, and 29Docetaxel 20 mg/m2 IV on Days 19 8,15,22, and 29Capecitabine 1000 mg/m2 PO

6、 BID on Days 1-7,15-21, and 29-35Given for 1 cycle16圍手術期化療：Epirubicin:阿表比星Prcopcrativc：術前Postoperative:術后PERIOPERATIVE CHEMOTHERAPY (INCLUDING EG JUNCTION)ECF (epirubicin, cisplatin, and 5FU)Epirubicin 50 mg/mIV on Day 1Cisplatin 60 mg/m2 IV on Day 15-FUI 200 mg/m2 IV continuous infusion over 24 hou

7、rs daily on Days 1-21 Cycled every 21 days for 3 cycles pre operatively and3 cycles postoperatively17ECF modificationsEpirubicin 50 mg/m2IV on Day 1Oxaliplatin 130 mg/m2 IV on Day 15-FU 200 mg/m2 IV continuous infusion over 24 hours daily on Days 1-21 Cycled every 21 days for 3 cycles pre operativel

8、y and3 cycles postoperatively18Epirubicin &0 mg/m2IV on Day 1Cisplatin 60 mg/m2 IV on Day 1Capecitabine 625 mg/m2 PO BID on Days 121Cycled every 21 days for 3 cycles pre operatively and3 cycles postoperatively18Epirubicin 50 mg/m2IV on Day 1Oxaliplatin 130 mg/m2 IV on Day 1Capecitabine 625 mg/m2 PO

9、BID on Days 1-21Cycled every 21 days for 3 cycles pre operatively and3 cycles postoperatively18序貫化療及外科放化療Irinotecan:伊立替康Riidiation：放療SEQUENTIAL CHEMOTHERAPY AND CHEMORADIATION (SURGICAL)Paclitaxel 50 mg/m2 IV on Day 1Cisplatin 30 mg/m2IV on Day 1Weekly with radiation for 5 weeks preoperative, thenPa

10、clitaxel 175 mg/m2 IV on Day 1Cisplatin 75 img/m2IV on Day 1Cycled every 21 days for 3 cycles postoperative19Preoperative docetaxel 75 mg/m2 IV on Day 1Cisplatin 75 mg/m2IV on Day 1Cycled every 21 days for 2 cyclesFollowed byDocetaxel 20 mg/m2 IV on Days 1,8,15, 22, and 29Cisplatin 25mg/m2 IV on Day

11、 1, 8.15,22, and 29Given fori cycle with radiationCisplatin 30 mg/m2 IV on Days 13 87 22, 29Irinotecan 50 mg/m2 IV on Days 1f 8, 22, 29With radiation preoperative, thenCisplatin 30 mg/m2 IV on Days 1 and 8Irinotecan 65 mg/m2 IV on Days 1 and 8Cycled every 21 days for 3 cycles postoperative19Preopera

12、tive cisplatin 30 mg/m2 IV on Days 1 and 8Irinotecan 65 mg/m2 IV on Days 1 and 8Cycled every 21 day& for 2 cyclesFollowed byCisplatin 30 mg/m2IVIrinotecan 65 mg/m引VGiven with radiation Days 1, ft, 15,22 or Days 19 8, 22, and 29?力Preoperative cisplatin 20 mg/m2 IV on Days 1-55-FU 200 mg/m2 IV continu

13、ous infusion over 24 hours daily on Days 1-21 Cycled every 28 days for 2 cyclesFollowed byPaclitaxel 45 ma/m2 IV on Day 15-FU 300 mg/m2IV continuous infusion ov&r 24 hours daily on Days 1-5 Weekly for 5 weeks with radiation13非外科治療化療方案Lcukovorin:甲酰四氫葉酸航貧血藥Cisplatin and fluonopYrimidineCisplatin 75-10

14、0 mg/m2 IV on Day 15-FU 750-1000 mg/m2IV continuous infusion over 24 hours daily on Days 1 -4Cycled every 28 days for 2-4 cycles for 2 cycles with radiation followed by 2 cycles without radiation21Cisplatin 30 mg/m2 IV on Day 1Capecitabine 800 mg/m2 PO BID on Days 1-5 Weekly for 5 weeksOxaliplatin a

15、nd fluoropyrimidineOxaliplatin 45-50 mg/m IVon Day 1 weekly for 5 weeks5-FU 225 mg/m IV continuous infusion over 24 hours daily on Days 1337Oxaliplatin 85 mg/m2IVon Days 1,15, and 29 for 3 doses5-FU 180 mg/m2 IV daily on Days 1-33Oxaliplatin 85 mg/m2IVon Days 1f 15, and 29 for 3 dosesCapecitab ine 6

16、25 mg/m5 PO BIDon Days 1-5 for 5 weeks&Oxaliplatin 85 mg/m2IV on Day 1 Leucovorin 400 mg/m2 IV on Day 15-FU 400 mg/m2 IVP on Day 15-FU 600 mg/m2 IV continuous infusion over 24 hours daily on Days 1 and 2Cycled every 14 days for 3 cycles with radiation followed by 3 cycles without radiation24Taxane a

17、nd cisplatinPaclitaxel 60 mg/m2IV on Days 1,8f 15, and 22Cisplatin 75 mg/m2 IV on Day 1Given for 1 cycle10Docetaxel 60 mg/m2 IV on Days 1 and 22 Cisplatin 60-80 mg/m2 IV on Days 1 and 22 Given for 1 cycle25Docetaxel 20-30 mg/m2 IV on Day 1 Cisplatin 20-30 mg/m2 IV on Day 1 Weekly for 5 weeks26Paclit

18、axel and carboplatinPaclitaxel 50 mg/m4 IV on Day 1Carboplatin AUC 2 IV on Day 1 Weekly for 5 weeks3Irinotecan mnd cisplatinIrinotecan 65 mg/m2IV on Days 1,8, 22, 29Cisplatin 30 mg/m2IV on Days 1,8f 22, 2912Taxane and fluoropyrimidinePaclitaxel 45-50 mg/m2 IV on Day 1Capecitabine 625-825 mg/m2 PO BID on Days 1-5 Weekly for 5 weeks114Docetaxel 20 mg/m2 IV on Day 15-FU 200-300 mg/m2 IV daily on Days 1-5Weekly for 5 weeks1516Docetaxel 20 mg/m2 IV on D