化療藥物配制指南

1、化療藥配備Common Antineoplastic Drug Pharmacy Preparation Chart Generic Name(INN)Trade NameConcentration /DiluentPrecautions /Stock SolutionStabilityVehicle forInfusionPrecautions /Ready-to-UseSolutionStabilityAmifostineEthyol500 mg in 9.7mL of 0.9% NaCl6 hrs (RT)24 hrs(refrigerated)n.r.Administerwithin

2、25 minutesAsparaginaseAsparaginase10,000 U in 4mL of WFIIn the dark,6 hrs)5% Dex / 0.9% NaCl AzathioprineImurek50 mg in 5-15mL of WFI120 hrs (RTor refrigerated)0.9% NaCl or 0.18% NaCl + 4% DexAdminister after preparationBleomycinBleomycin Numerous incompatibilities0.9% NaCl Carboplati

3、nCarboplat50 mg in 5 mLIn the dark5% Dex / 0.9% NaCl Conc > 0.5 mg/mL8 hrs (RT) 24 hrs (refrigerated)Carmustine(BCNU)CarmubrisDissolve in 3 mL of ethanol, add 27 mL of WFI100 mg in 30 mL5% Dex / 0.9% NaCl0.9% NaCl8 hrs (RT)24 hrs (refrigerated)CisplatinPlatinex50 mg in 100 mLIn the dark, RT0.9% N

4、aCl8 hrs (RT)CladribineLeustatin10 mg in 10 mL 0.9% NaClAdminister within < 8 hrs (refrigerated)CyclophosphamideEndoxan1,000 mg in 50 mL of WFI24 hrs (refrigerated)5% Dex / 0.9% NaCl CytarabineAlexan100 mg in 5 mL 5% Dex / 0.9% NaCl Dacarbazine(DTIC)Detimedac100 mg in 10 mL of

5、 WFIIn the dark; prepare immediately before use5% Dex / 0.9% NaClAdminister within < 30 minDactinomycinLyovac-CosmogenDissolve in 1.1 mL of WFI 0.5 mg in 1 mLIn the dark5% Dex / 0.9% NaCl DaunorubicinDaunoblastin100 mg in 10 mL of WFIIn the dark, 24 hrs (RT), 48 hrs (refrigerated)  

6、;DocetaxelTaxotere80 mg in 8 mLPrepare immediately before use5% Dex / 0.9% NaCl Conc < 0.74 mg/mL4 hrs (RT)Doxorubicin(Adriamycin)Adriblastin50 mg in 25 mLIn the dark, refrigeratedN/A, bolusInject within 10-15 minEpirubicinFarmorubicin50 mg in 25 mLIn the dark, refrigeratedN/A, bolusInject within

7、 10-15 minEstramustinePhosphateEstracyt300 mg in 8 mL of WFIPrepare immediately before use5% Dex NO NaCl!12 hrs (RT)24 hrs (refrigerated)EtoposideVepesid J100 mg in 5 mL 5% Dex / 0.9%24 hrs at 0.4EtoposidePhosphateEtopophos100 mg of etoposide in 10 mL of WFI, 5% Dex , or 0.9% NaClAdminister aft

8、er preparation5% Dex / 0.9% NaCl Conc > 0.1 mg/mLAdminister after preparationFilgrastim(G-CSF)Neupogen300 µg in 1 mLRefrigerated5% Dex. NO NaCl Conc > 2 µg/mL24 hrs (refrigerated)FludarabineFludara50 mg in 2 mL of WFI8 hrs5% Dex / 0.9% NaCl Fluorouracil(5-FU)Fluroblastin1,000 mg

9、 in 20 mLIn the dark, RT5% Dex Folinic AcidCalcium SaltPentahydrateLeucovorin200 mg in 20 mLIn the dark0.9% NaCl GemcitabineGemzar200 mg in 5 mL of NaCl24 hrs (RT);DO NOT REFRIGERATE0.9% NaClAdminister within 30 minIdarubicinZavedos10 mg in 10 mL of WFI24 hrs (refrigerated)N/A, bolusInject

10、 within 10-15 minIfosfamideHoloxan1,000 mg in 25 mL of WFI48 hrs (refrigerated)5% Dex / 0.9% NaCl Interferonalfa-2aRoferon A3,000,000 U in 1 mLIn the dark, refrigeratedN/ASC or IMInterleukin-2ProleukinDissolve in 1.2 mL of WFI18,000,000 U in 1 mL24 hrs5% Dex + 0.1% HAAdminister after preparatio

11、nm-AMSAAmsidyl1.5 mL of concentrate in 13.5 mL of soln (glass syringe) 75 mg in 15 mLIn the dark, 8 hrs5% Dex NO NaCl!Administer within 60-90 minMelphalanAlkeran50 mg in 10 mL of solution / diluentIn the dark, RT; prepare immediate-ly before use0.9% NaCl. No Dex!Administer within < 90 minMethotre

12、xateMethotrexate50 mg in 2 mLIn the dark5% Dex / 0.9% NaCl Mitomycin CMitomycin10 mg in 10 mL of WFIIn the dark; prepare immediately before use5% Dex / 0.9% NaCl3 hrs in 5% DexMitoxantroneNovantrone,Onkotrone20 mg in 10 mL7 days once opened5% Dex / 0.9% NaCl48 hrsNimustineACNU50 mg in 10 mL of

13、WFIPrepare immediately before useN/AInject IV after preparationPaclitaxelTaxol30 mg in 5 mLIn the dark, RT5% Dex / 0.9% NaCl Conc 0.3-1.2 mg/mL27 hrs (RT);DO NOT REFRIGERATE!USE PVC-FREE GIVING SETS!PentostatinNipent10 mg in 5 mL of WFI8 hrs (RT)n.r.Administer IV or diluted within 20-30 minTeniposid

14、eVM 2650 mg in 5 mLIn the dark5% Dex / 0.9% NaCl Conc 0.1 mg/mL24 hrs (RT);O NOT REFRIGERATE!USE PVC-FREE GIVING SETS!ThiotepaThiotepa15 mg in 1.5 mL of WFIRefrigerate; prepare immediately before use5% Dex / 0.9% NaCl TopotecanHycamtin4 mg in 4 mL of WFI12 hrs (RT),24 hrs (refrigerated)5% Dex /

15、 0.9% NaCl Conc 25-50 µg/mL TreosulfanOvastat1,000 mg in 20 mL of WFI8 hrsn.r. VinblastineVelbe10 mg in 10 mL of NaClPrepare immediately before useN/AInject IV within < 1 minVincristineVincristine1 mg in 1 mLIn the dark, 14 days (refrigerated)5% Dex / 0.9% NaCl VindesineEldisine5 mg in 5 mL30 days(refrigerated)N/AInject IVVinorelbineNavelbine10 mg in 1 mL of WFI 5% Dex / 0.9% NaClAdminister wit