Corylifol-A-Corylifol-A-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECorylifol ACat. No.: HY-N0897CAS No.: 775351-88-7Synonyms: Corylifol-A; Corylinin分式: CHO分量: 390.47作靶點(diǎn): STAT作通路: JAK/STAT Signaling; Stem Cell/Wnt儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMS

2、O : 15.4 mg/mL (39.44 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.5610 mL 12.8051 mL 25.6102 mL5 mM 0.5122 mL 2.5610 mL 5.1220 mL10 mM 0.2561 mL 1.2805 mL 2.5610 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Corylifol A 能夠抑制I

3、L-6 誘導(dǎo)的 STAT3 的激活和磷酸化，其IC50 值為0.81 M。IC50 & Target STAT30.81 M (IC50)1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE體外研究 Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 valueof 0.810.15 M, also inhibits STAT3 phosphorylation induced by IL-6 i

4、n Hep3B cells 1. Corylifol A inhibitsSARA PLpro in a dose-dependent manner with IC50s ranging between 4.2 and 38.4 M 2. Corylifol A isfound to be a naturally occurring potent inhibitor of hCE2, with low Ki values ranging from 0.62 M to 3.89 M3.REFERENCES1. Lee SW, et al. Phenolic compounds isolated

5、from Psoralea corylifolia inhibit IL-6-induced STAT3 activation. Planta Med. 2012Jun;78(9):903-6.2. Kim DW, et al. Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia. JEnzyme Inhib Med Chem. 2014 Feb;29(1):59-63.3. Li YG, et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2. Fitoterapia.2015 Jan 13;101C:99-106. dMcePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37