Dopamine-ASL279-free-base-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEDopamineCat.No.:HY-B0451CASNo.:51-61-6Synonyms:ASL279freebase分?式:C?H??NO?分?量:153.18作?靶點:DopamineReceptor;EndogenousMetabolite;Ferroptosis作?通路:GPCR/GProtein;NeuronalSignaling;MetabolicEnzyme/Protease;Apoptosis儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Dopamine在腦?質(zhì)，腦腹側(cè)被蓋區(qū)和下丘腦中產(chǎn)?的?種?茶酚胺類神經(jīng)遞質(zhì)，在?腦和?體中起重要作?[1]。Dopamine通過D2多巴胺受體(D2dopaminereceptor)來誘導(dǎo)VEGFR2的內(nèi)吞作?，這對于促進?管?成?關(guān)重的[2]。IC50&TargetHumanEndogenousMetaboliteMicrobialMetaboliteD2DopamineReceptor體外研究Vascularpermeabilityfactor/vascularendothelialgrowthfactor(VPF/VEGF)stronglystimulateshumanumbilicalveinendothelialcells(HUVECs)proliferation.ThestimulatoryeffectofVPF/VEGFisabrogatedbyDopamine(1μM;24hours)[2].CellProliferationAssay[2]CellLine:HUVECsConcentration:1μMIncubationTime:24hoursResult:InhibitedVPF/VEGF-inducedHUVECproliferationspecificallythroughitsD2receptor.體內(nèi)研究Dopamine(50mg/kg;i.p.injection;days1-7)stronglyandselectivelyinhibitsthevascularpermeabilizingandangiogenicactivitiesofVPF/VEGF[2].1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEAnimalModel:SyngeneicC3Heb/FeJmicewithMOTascitestumors[2]Dosage:50mg/kgAdministration:I.p.injection;7daysResult:Correspondingto~5%ofthemedianlethaldose(LD50)inmice)beginningat24hoursaftertumor-cellinjectionandcontinuingdailyfor7days.戶使?本產(chǎn)品發(fā)表的科研?獻?BiomedPharmacother.2019Nov;119:109419.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].JuárezOlguínH,etal.TheRoleofDopamineandItsDysfunctionasaConsequenceofOxidativeStress.OxidMedCellLongev.2016;2016:9730467.[2].BasuS,etal.Theneurotransmitterdopamineinhibitsangiogenesisinducedbyvascularpermeabilityfactor/vascularendothelialgrowthfactor.NatMed.2001May;7(5):569-74.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:4