乳腺癌五或更長(zhǎng)期的輔助內(nèi)分泌治療：一項(xiàng)已發(fā)表的隨機(jī)試驗(yàn)的meta分析ppt課件講座

1、L/O/G/O煩惱有何懼怕，既然躲不掉，就調(diào)好心態(tài)與它共存。心向陽(yáng)光，何懼風(fēng)霜。煩惱有何懼怕，既然躲不掉，就調(diào)好心態(tài)與它共存。心向陽(yáng)光，何懼風(fēng)霜。茫茫人海你我相遇就是緣分，歡迎下載！茫茫人海你我相遇就是緣分，歡迎下載！乳腺癌五年或更長(zhǎng)期的輔助內(nèi)分泌治療：乳腺癌五年或更長(zhǎng)期的輔助內(nèi)分泌治療：一項(xiàng)已發(fā)表的隨機(jī)試驗(yàn)的一項(xiàng)已發(fā)表的隨機(jī)試驗(yàn)的metameta分析分析Fausto PetrelliBreast Cancer Res Treat 2013-6-2822021/8/12一、背景介紹一、背景介紹330%40%2021/8/12一、背景介紹一、背景介紹4 12000BC 5年年VS10年年TAM治

2、療治療中位隨訪中位隨訪13.6年：減少總生存及晚期年：減少總生存及晚期BC發(fā)生發(fā)生子宮內(nèi)膜癌發(fā)生風(fēng)險(xiǎn)子宮內(nèi)膜癌發(fā)生風(fēng)險(xiǎn)(3.1 vs. 1.6 %),死亡風(fēng)險(xiǎn)增加死亡風(fēng)險(xiǎn)增加0.2%。10年年TAM，減少，減少BC復(fù)發(fā)風(fēng)險(xiǎn)復(fù)發(fā)風(fēng)險(xiǎn)(P = 0.003), BC 相相關(guān)死亡風(fēng)險(xiǎn)關(guān)死亡風(fēng)險(xiǎn) (P = 0.05) ，整體死亡風(fēng)險(xiǎn)，整體死亡風(fēng)險(xiǎn) (P = 0.1), 第九年后的獲益更大。第九年后的獲益更大。5年年TAM 來(lái)曲唑來(lái)曲唑/安慰劑，安慰劑，64個(gè)月的中位隨訪中，個(gè)月的中位隨訪中，顯著降低復(fù)發(fā)風(fēng)險(xiǎn)，但顯著降低復(fù)發(fā)風(fēng)險(xiǎn)，但OS相近。相近?？紤]了揭盲后，安慰劑組中考慮了揭盲后，安慰劑組中66%應(yīng)用

3、了來(lái)曲唑，提應(yīng)用了來(lái)曲唑，提示來(lái)曲唑顯著提高了示來(lái)曲唑顯著提高了DFS和和OS 。2021/8/12二、研究方法二、研究方法 1.數(shù)據(jù)來(lái)源5電子搜索2021/8/12二、研究方法二、研究方法 2.研究選擇/數(shù)據(jù)提取6入選標(biāo)準(zhǔn)入選標(biāo)準(zhǔn)提取數(shù)據(jù)提取數(shù)據(jù)早期乳腺癌患者早期乳腺癌患者RCT:比較比較5年及更久內(nèi)分泌治年及更久內(nèi)分泌治療療開(kāi)始開(kāi)始2013-6-11研究由兩名研究人員分別選擇，出現(xiàn)分歧時(shí)有第三名研究人員評(píng)議。研究由兩名研究人員分別選擇，出現(xiàn)分歧時(shí)有第三名研究人員評(píng)議。英文發(fā)表英文發(fā)表基本信息：雜志名、發(fā)表年份、作者名基本信息：雜志名、發(fā)表年份、作者名人口統(tǒng)計(jì)學(xué)：中位年齡、淋巴結(jié)水平、人口統(tǒng)

4、計(jì)學(xué)：中位年齡、淋巴結(jié)水平、月經(jīng)狀態(tài)、原發(fā)腫瘤的激素水平月經(jīng)狀態(tài)、原發(fā)腫瘤的激素水平研究信息：樣本量、研究設(shè)計(jì)、研究終點(diǎn)研究信息：樣本量、研究設(shè)計(jì)、研究終點(diǎn)治療方案治療方案結(jié)果結(jié)果 （率或事件數(shù)）：（率或事件數(shù)）：OS, 無(wú)復(fù)發(fā)生存無(wú)復(fù)發(fā)生存(RFS), 乳腺癌相關(guān)生存乳腺癌相關(guān)生存(BCSS), 非癌癥相關(guān)非癌癥相關(guān)死亡死亡, 局部或遠(yuǎn)處的局部或遠(yuǎn)處的 RFS (LR-RFS/D-RFS)人類(lèi)研究人類(lèi)研究2021/8/12二、研究方法二、研究方法72021/8/12三、結(jié)果三、結(jié)果82021/8/12三、結(jié)果三、結(jié)果92021/8/12三、結(jié)果三、結(jié)果102021/8/12三、結(jié)果三、結(jié)果1

5、12021/8/129、 人的價(jià)值，在招收誘惑的一瞬間被決定。22.3.722.3.7Monday, March 07, 202210、低頭要有勇氣，抬頭要有低氣。23:49:0523:49:0523:493/7/2022 11:49:05 PM11、人總是珍惜為得到。22.3.723:49:0523:49Mar-227-Mar-2212、人亂于心，不寬余請(qǐng)。23:49:0523:49:0523:49Monday, March 07, 202213、生氣是拿別人做錯(cuò)的事來(lái)懲罰自己。22.3.722.3.723:49:0523:49:05March 7, 202214、抱最大的希望，作最大的努力

6、。2022年3月7日星期一下午11時(shí)49分5秒23:49:0522.3.715、一個(gè)人炫耀什么，說(shuō)明他內(nèi)心缺少什么。2022年3月下午11時(shí)49分22.3.723:49March 7, 202216、業(yè)余生活要有意義，不要越軌。2022年3月7日星期一23時(shí)49分5秒23:49:057 March 202217、一個(gè)人即使已登上頂峰，也仍要自強(qiáng)不息。下午11時(shí)49分5秒下午11時(shí)49分23:49:0522.3.7三、結(jié)果三、結(jié)果13ER+2021/8/12三、結(jié)果三、結(jié)果14兩組中相似36%，P=0.0213%，P=0.022021/8/12三、結(jié)果三、結(jié)果152021/8/12四、討論四、討

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