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A11A2A36A2酶法合成7ACA及頭孢菌素類抗生素的研究進(jìn)展A0A4A5A6A7A8A9A10A11A8A12A13A14A15A16A17A18A19A20A21A22A23A24A25A26A27A28A29A22A30A31A32A33A34A35A27A36A37A30A31A32A33A38A39A40A41A42A9A10A11A8A43A44A45A46A47A32A33A48A49A25A50A51A47A52A53A54A55A56A57A58A47A59A60A61A30A31A32A33A62A39A63A64A5A6A65A66A67A62A39A68A69A68A70A71A5A6A72A73A71A5A6A63A74A71A5A6A75A76A22A32A33A77A31A56A78A79A80A5A6A7A8A37A30A31A32A33A37A62A39A68A69A68PROGRESSINENZYMATICSYNTHESISOF7ACAANDCEPHALOSPORINSABSTRACTCEPHALOSPORINSANTIBIOTICSPLAYEDANIMPORTANTROLEINPHARMACEUTICALINDUSTRYENZYMATICSYNTHESISA81LACTAMANTIBIOTICSCOULDDECLINETHEGENERATIONOFWASTEANDTHECOSTOFPRODUCTIONREMARKABLYTHISREVIEWFOCUSESONTHERECENTPROGRESSESOFENZYMATICSEMISYNTHESISOF7ACAA82CA83A84A85A86A87A88A89A90A82A91A83A84A85A88A83A92A89A90A85A90A93A91A83A84A94A85A93A89A90A83A95KEYWORDSCEPHALOSPORINENZYMATICSYNTHESIS7ACAA96A97A98A99A100A101A102A103A104A105A106A107A108A105A109A110A111A112A105A109A110A113A114A115A116A117A105A118A109A119A120A121A114A122A123A96A124A98A125A126A100A101A127A128A129A130A131A132A133A134A135A136A96A100A101A137A138A139A140A141A142A143A119A120A121A114A144A145A146A147A148A149A150A151A152A153A154A155A156A157A158A159A160A161A162A163A164A165A166A152A167A168A169A170A164A171A172A173A174A175A176A162A177A162A163A178A179A180A181A182A183A184A185A186A187A188A189A190A191A192A193A164A194A195A196A197A198A199A200A201A202A203A204A205A163A195A206A207A208A209A210A190A191A192A193A211A212A213A214A215A216A217A152A218A219A188A189A156A157A158A159A160A161A162A163A152A220A210A221A222A223A178A179A224A225A226A156A208A227A228A209A210A229A230A231A232A233A234A152A235A236A237A238A239A240A241A242A243A164A244A245A152A246A247A237A242A248A164A249A250A152A190A191A192A193A251A252A233A234A164A253A254A255A27A208A59A172A198A60A196A197A0A1A64A59A172A65A2A65A67A252A162A163A196A197A191A177A3A176A162A177A164A249A244A4A5A22A196A197A191A177A6A7A8A9A10A11A12A189A171A172A173A174A175A37A203A204A205A206A13A208A208A14A15A16A17A18A17A190A19A20A161A164A18A17A21A23A22A215A24A25A26A28A29A216A14A30A31A193A32A33A37A203A22A15A16A210A17A164A34A193A22A226A35A228A36A38A39A40A164A41A193A22A234A42A38A39A164A43A44A45NSORCONHRCOOHCH2X21345687A46A47A48A49A50A51A52A53A547ACAA238A55A56A57A58A61A62A63A66A68A69A70A71A72A241A73A238A74A73A75A76A77A72A241A117A62A63A78A79A80A81A82A83A84A61A66A68A85A69A70A240A86A87A88A73A238A89A90A73A91A92A93A85A72A241A73A62A63A94A95A96A97A72A98A109A62A98A188A99A238A100A188A99A61A101A102A103A62A63A101A102A104A98A160A105A106A107A108A110A111A112A113A114A115A116A118A61A119A120A121A122A123A85A227A74A73A62A63A66A68A124A72A241A73A125A126A85A199A127A128A71A129A106A130A131A85A141A132A115A114A66A68A133A134A85A135A136A137A103A107A108A110A111A138A238A85A139A140A142A143A144A145A103A146A147A61A148A149A238A150A151A152A153A145A217A154A155A156A188A99A238A100A188A99A101A102A85A157A158A159A72A241A62A63A144A161A156A1622A163A1646A163A61A165A166A219A167A103A168A169A183A170A171A172A173A174A85A175A176A159A119A120A61A177A178A77A179A180A85A84A74A73A181A182A184A185A186A187A186A154A55A56A57A58A61A117A62A63A151A182A159A189A190A183A188A66A68A61A192A76A130A195A77A193A194A196A143A197A198A184A185A186A187A186A75A160A74A73A98A200A160A74A73A154A55A56A57A58A201A115A58A74A73A62A63A61A202A207A202A209A159A211A21217氨基頭孢烷酸7ACA的酶法合成A184A185A213A214A55A56A216A218A80A220A221A66A222A115A114A117A62A63A55A56A57A58A61A223A70A144A224A151A225A229A230A231A95A66A222A232A106A233A84A72A241A73A199A55A56A57A58A187A235A236A237A239A242A243A100A244A245A246A198A115A114A77A247A72A241A73A94A95A66A68A248A249A98A63A193A146A121A250A251A225A227A252A253A254A255A223A74A0A183A170A77A124A72A241A73A125A126A225A74A73A76A1A2A217A114A115A114A101A102A116A116A133A72A204A79A141A80A105A81A171A172A61A55A56A57A58A187A162A156A202A82A196A2A84A127A74A1A83A115A114A101A102A144A84A71A84A172A71A165A35A3A83A2A78A4A5A188A99A3A238A100A188A99A3A121A160A105A207A225A114A25A6A90A7A172A146A92A46A98A146A167A118A225A93A8A9A10A63A193A238A175A176A74A0A77A179A180A143A197A198A56A11A96A97A202A209A74A73A115A114A184A185A186A187A186A61A19A12A77A13A14A13A17A15A16A18A20A21A21A23A23A24A22A26A22A81A82A56A11A19A12A107A106A61A80A75A160A74A73A27A28A184A185A186A187A186A77A98A166A225A55A56A57A58A187A95A83A99A29A30A31A32A33A34A185A213A214A218A99A72A74A204A34A36A77A37A38A39A40A77A41A38A42A40A43A38A42A77A106A75A44A45A47A47A48A49A50A51A52A214A53A44A54A55A57A58A108A61A59A60A62A63A64A109A75A110A40A77A42A38A65A66A67A68A69A77A37A38A39A40A41A75A65A70A77A67A40A106A65A40A71A77A39A38A41A77A41A38A42A44A109A75A110A40A69A68A69A47A72A47A49A50A73A52A238A85A86A48A86A87A113A88A60A62A63A170A89A115A91A44A122A116A94A95A96A100A54A55A59A85A86A48A86A53A117A101A53A102A103A44A212A119A104A120A111A112A61A69A68A69A118A61A121A123A124A125A64A126A67A127A110A77A71A66A67A68A69A77A37A38A39A40A41A75A65A70A77A67A40A106A65A40A71A77A39A38A41A77A41A38A42A44A128A129A69A68A69A47A72A47A49A44A193A130A128A129A69A68A69A47A72A47A131A128A129A69A68A69A47A72A47A112A53A132A64A128A129A69A68A69A47A72A47A77A41A66A67A77A106A75A49A59A133A246A134A102A135A136A137A138A44A55A1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